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Potential anticancer agents. 17. Analogues of methotrexate with a tripeptide side chain

D C Suster, E Tărnăuceanu, G Botez

Journal of Medicinal Chemistry

|November 1, 1978

Abstract:

Nine tripeptide analogues of methotrexate were synthesized from 2,4-diamino-6-(chloromethyl)pteridine. Only N-[N-[4-[2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]glycyl-DL-aspartic acid (1a) showed moderate activity against L1210 murine leukemia (ILS = 69%) and W 256 carcinosarcoma (TGI = 55%).

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