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Transient hypoproteinemia and hypoprothrombinemia in an infant

D Hardoff, D Attias

    European Journal of Pediatrics
    |May 1, 1981
    PubMed

    Insights

    This study describes an infant with low protein and prothrombin levels due to protein losing enteropathy. Menetrier

    Area of Science:

    • Pediatric Gastroenterology
    • Hematology

    Background:

    • Transient hypoproteinemia and hypoprothrombinemia can occur in infants.
    • Protein losing enteropathy is a condition characterized by excessive protein loss through the gastrointestinal tract.

    Observation:

    • A 7-month-old infant presented with transient hypoproteinemia and hypoprothrombinemia.
    • Menetrier's disease was considered a potential cause for protein loss.

    Findings:

    • Hypoproteinemia was attributed to protein losing enteropathy.
    • Hypoprothrombinemia, in the absence of vitamin K deficiency, may result from prothrombin loss into the gut, given its lower molecular weight compared to albumin.

    Implications:

    • This case highlights a potential mechanism for hypoprothrombinemia in infants with protein losing enteropathy.
    • Understanding differential protein loss is crucial for diagnosing and managing such conditions.

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