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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
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Published on: January 2, 2017

Cefadroxil monohydrate versus erythromycin in paediatric patients

H Trujillo

    The Journal of International Medical Research
    |January 1, 1981
    PubMed

    Insights

    Cefadroxil monohydrate demonstrated higher efficacy than erythromycin estolate in treating pediatric upper respiratory tract infections, achieving a 95% cure rate. This study highlights cefadroxil

    Area of Science:

    • Pediatric infectious diseases
    • Pharmacology
    • Microbiology

    Background:

    • Upper respiratory tract infections (URTIs) are common in children.
    • Antibiotic resistance is a growing concern in treating bacterial infections.
    • Cephalosporins and macrolides are frequently used antibiotics for URTIs.

    Purpose of the Study:

    • To compare the efficacy of cefadroxil monohydrate versus erythromycin estolate in treating pediatric URTIs.
    • To evaluate clinical and bacteriological cure rates for both antibiotic treatments.
    • To assess the impact of antibiotic resistance on treatment outcomes.

    Main Methods:

    • A comparative study involving forty pediatric patients with URTIs.
    • Patients were randomized into two groups: twenty receiving cefadroxil monohydrate and twenty receiving erythromycin estolate.
    • Both drugs were administered orally at 50 mg/kg/day, divided into two doses every 12 hours.

    Main Results:

    • Cefadroxil monohydrate achieved a complete cure rate of 95%, compared to 80% for erythromycin estolate.
    • Two patients treated with erythromycin estolate showed no improvement due to S. aureus resistant to erythromycin; they were successfully treated with cefadroxil.
    • In scarlet fever cases, cefadroxil demonstrated superior bacteriological eradication compared to erythromycin.

    Conclusions:

    • Cefadroxil monohydrate is a highly effective treatment for pediatric URTIs, showing better efficacy than erythromycin estolate.
    • The study underscores the importance of considering bacterial resistance patterns, such as erythromycin resistance in S. aureus.
    • Cefadroxil monohydrate offers a reliable therapeutic option for pediatric URTIs, including those caused by resistant pathogens.

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