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Related Experiment Videos

Occupational exposure to N-nitroso compounds

C Rappe, T Rydström

    IARC Scientific Publications
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    N-Nitrosodiphenylamine in rubber additives can form harmful N-nitrosamines. While not carcinogenic itself, it reacts with other rubber chemicals to create potentially dangerous compounds, posing a risk in the rubber industry.

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    Area of Science:

    • Chemical Safety
    • Industrial Chemistry
    • Toxicology

    Background:

    • N-Nitrosodiphenylamine is a common additive in rubber manufacturing.
    • This specific N-nitrosamine has not demonstrated carcinogenic effects in animal studies.
    • It is known to act as a transnitrosation agent.

    Purpose of the Study:

    • To investigate the potential for N-Nitrosodiphenylamine to form other N-nitrosamines in rubber mixtures.
    • To identify the precursor chemicals involved in this transnitrosation process.
    • To assess the indirect risks associated with N-Nitrosodiphenylamine in industrial applications.

    Main Methods:

    • Analysis of chemical reactions within rubber formulations containing N-Nitrosodiphenylamine.
    • Identification of secondary N-nitrosamines formed through transnitrosation.

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  • Examination of common rubber additives like di-n-butylamine and tetramethylthiuram disulfide.

    • Main Results:

    • N-Nitrosodiphenylamine effectively acts as a transnitrosation agent in rubber mixtures.
    • The reaction forms other N-nitrosamines, such as N-nitrosodibutylamine and N-nitrosodimethylamine.
    • These reactions occur with other industrial additives present in the rubber compound.

    Conclusions:

    • N-Nitrosodiphenylamine, despite lacking direct carcinogenicity, poses an indirect risk in the rubber industry.
    • Its role as a transnitrosation agent necessitates careful consideration of co-additives.
    • The formation of secondary N-nitrosamines highlights potential safety concerns in rubber product manufacturing.