Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Administration o gentamicin to obese patients

S Korsager

    International Journal of Clinical Pharmacology, Therapy, and Toxicology
    |December 1, 1980
    PubMed
    Summary

    Obese patients show a lower apparent volume of distribution (AVD) for gentamicin compared to normal-weight individuals. This study recommends an adjudged body weight formula for calculating gentamicin dosage in severe obesity cases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [The effects of captopril and metoprolol on blood pressure and side effects in patients with mild to moderate hypertension].

    Ugeskrift for laeger·1989
    Same author

    [Acetylsalicylic acid and indomethacin in the treatment of idiopathic orthostatic hypotension and Shy-Drager's syndrome].

    Ugeskrift for laeger·1985
    Same author

    Dementia and central nervous system involvement in chronic lymphocytic leukaemia.

    Scandinavian journal of haematology·1982
    Same author

    [Thyroid diseases in Down's syndrome].

    Ugeskrift for laeger·1981
    Same author

    [Autoimmunity in Down's syndrome].

    Ugeskrift for laeger·1981
    Same author

    Antiglobulin-tests for detection of auto-immunohaemolytic anaemia during long-term treatment with ibuprofen.

    Scandinavian journal of rheumatology·1981

    Area of Science:

    • Pharmacokinetics
    • Obesity Medicine
    • Clinical Pharmacology

    Background:

    • Gentamicin dosing requires careful consideration of body composition.
    • Obesity significantly alters drug distribution and elimination.
    • Understanding gentamicin pharmacokinetics in obese individuals is crucial for effective treatment.

    Purpose of the Study:

    • To investigate the relationship between a single gentamicin dose and serum concentration in obese and normal-weight patients.
    • To determine the apparent volume of distribution (AVD) of gentamicin in different weight groups.
    • To propose a dosing adjustment for gentamicin in severe obesity.

    Main Methods:

    • Studied 17 obese patients (82.7% excess weight) and 10 normal-weight controls.
    • Administered a single bolus dose of gentamicin.
    • Calculated the apparent volume of distribution (AVD) for gentamicin in both groups.
    • Determined AVD for adipose tissue and lean body mass.

    Main Results:

    • Obese patients had a significantly lower AVD (17.7%) compared to normal-weight patients (23.2%).
    • AVD for adipose tissue was 10.3% and for lean body mass was 31.0%.
    • Gentamicin uptake in adipose tissue represented 43.7% of total body mass uptake in normal-weight patients.

    Conclusions:

    • Gentamicin distribution is altered in obese individuals, necessitating dose adjustments.
    • An adjudged body weight formula is recommended for calculating gentamicin doses in severe obesity.
    • Further research may refine gentamicin dosing strategies for diverse patient populations.

    Related Experiment Videos