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[Peritoneal dialysis therapy in psoriasis]

H D Göring, H Thieler, G Güldner

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |April 1, 1981
    PubMed
    Summary
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    Peritoneal dialysis effectively treated psoriasis vulgaris in three patients unresponsive to standard therapies. This treatment led to long-term remission and favorable immunological changes.

    Area of Science:

    • Dermatology
    • Nephrology
    • Immunology

    Background:

    • Psoriasis vulgaris is a chronic autoimmune skin condition.
    • Standard dermatological treatments often fail for long-term, severe cases.
    • The underlying immunological mechanisms of psoriasis are complex.

    Observation:

    • Three patients with chronic, treatment-resistant psoriasis vulgaris were treated with peritoneal dialysis.
    • Psoriatic lesions completely cleared following the dialysis procedure.
    • Remission was sustained for three to six months post-treatment.

    Findings:

    • Peritoneal dialysis induced significant immunological changes in patients.
    • An increase in E-rosette forming cells was observed.
    • A decrease in serum soluble immune complex concentration was noted.

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    Implications:

    • Peritoneal dialysis may represent a novel therapeutic approach for refractory psoriasis vulgaris.
    • Modulation of immune parameters by dialysis could be key to remission.
    • Further research is warranted to explore dialysis-based therapies for autoimmune skin diseases.