Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fast integrated flow plethysmograph for small mammals

E E Sinnett, A C Jackson, D E Leith

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |May 1, 1981
    PubMed
    Summary

    Accurate forced vital capacity (FVC) measurements in small mammals need high-frequency response plethysmographs. This study details plethysmograph behavior, presents a mouse-sized device

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Negative and positive mental health characteristics of affected family members: Findings from a cross-sectional Australian general population gambling study.

    Addictive behaviors·2024
    Same author

    Electricity: A Paper Read before the Union Medical Society of Northern Indiana.

    The North-Western medical and surgical journal·2023
    Same author

    Retrospective observational study of patient outcomes with local wound infusion vs epidural analgesia after open hepato-pancreato-biliary surgery.

    BMC anesthesiology·2022
    Same author

    Correction to: A Composite Measure of Gambling Exposure: Availability, Accessibility or Both?

    Journal of gambling studies·2021
    Same author

    Correction to: The Relative and Interactive Effects of Actual and Perceived Gambling Exposure on Gambling Behaviour.

    Journal of gambling studies·2021
    Same author

    The Relative and Interactive Effects of Actual and Perceived Gambling Exposure on Gambling Behaviour.

    Journal of gambling studies·2021

    Area of Science:

    • Physiology
    • Respiratory Medicine
    • Biomedical Engineering

    Background:

    • Accurate forced vital capacity (FVC) measurement in small mammals necessitates plethysmographs with superior high-frequency response characteristics.
    • Understanding the theoretical behavior of different plethysmograph orders (zeroth, first, and second) is crucial for optimizing measurement accuracy.

    Purpose of the Study:

    • To theoretically analyze the frequency response of zeroth, first, and second-order plethysmographs.
    • To present the actual frequency response of a mouse-sized plethysmograph and introduce a method for enhancing its performance.
    • To provide design criteria for plethysmographs suitable for both small and larger animals.

    Main Methods:

    • Theoretical development of plethysmograph behavior based on their order (pressure vs. flow type, with/without inertance).
    • Experimental measurement of the frequency response of a mouse-sized plethysmograph.
    • Development and application of a technique to improve the plethysmograph's response characteristics.

    Main Results:

    • A flat amplitude response (within 3% of reference) was achieved for sinusoidal inputs below 240 Hz.
    • A minimal phase lag, equivalent to a 1.4 ms time delay, was observed up to 150 Hz.
    • A typical forced vital capacity curve for a mouse was successfully recorded.

    Conclusions:

    • The developed technique significantly improves the high-frequency response of mouse-sized plethysmographs.
    • The findings provide a foundation for designing accurate plethysmographs for various small and large animal models.
    • Optimized plethysmography is essential for reliable respiratory function assessment in preclinical research.

    Related Experiment Videos