Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Lymphangiosarcoma after filarial infection

E M Sordillo, P P Sordillo, S I Hajdu

The Journal of Dermatologic Surgery and Oncology

|March 1, 1981

Summary

This study reports the first case of lymphangiosarcoma in a lower limb due to chronic lymphedema from childhood filariasis. The rare cancer showed calcifications and had a surprisingly long patient survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Intermediate cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis successfully treated with fluconazole.

Clinical and experimental dermatology·2014

Same author

Lymphoepithelioma-like gastric carcinoma: an unusual consequence of Epstein-Barr virus infection in an HIV-infected woman.

International journal of STD & AIDS·2013

Same author

Multiple skin nodules in a recreational gardener from New York.

Clinical and experimental dermatology·2011

Same author

Successful treatment of Old World cutaneous leishmaniasis caused by Leishmania infantum with posaconazole.

Antimicrobial agents and chemotherapy·2011

Same author

Use and efficacy of tuberculosis infection control practices at hospitals with previous outbreaks of multidrug-resistant tuberculosis.

Infection control and hospital epidemiology·2001

Same author

Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression.

Proceedings of the National Academy of Sciences of the United States of America·2001

Area of Science:

Oncology
Parasitology
Vascular Medicine

Background:

Chronic lymphedema can develop after filarial infections, particularly in lower extremities.
Lymphangiosarcoma is a rare malignancy typically associated with chronic lymphedema, often seen post-mastectomy.
Filarial infections are a common cause of secondary lymphedema in endemic regions.

Observation:

A unique case of lymphangiosarcoma in the lower extremity of a patient with a history of childhood filariasis is presented.
Histological examination revealed a neoplasm similar to other lymphangiosarcomas but with distinct areas of calcification.
Calcifications, indicative of prior filarial infection, were observed within the tumor and surrounding muscle tissue.

Findings:

This is the first documented instance of lymphangiosarcoma arising in the context of chronic lymphedema caused by filariasis.
The observed calcifications within the tumor and adjacent muscle provide direct evidence of the filarial etiology.
The patient exhibited prolonged survival, which is atypical for lymphangiosarcoma.

Implications:

This case expands the known etiological associations of lymphangiosarcoma.
It highlights the potential long-term complications of chronic filarial lymphedema.
Further research may explore the specific mechanisms linking filariasis-induced lymphedema to lymphangiosarcoma development and prognosis.

Related Experiment Videos