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Does ethanol damage the blood--brain barrier?

S C Phillips

    Journal of the Neurological Sciences
    |April 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    This study shows that chronic or acute ethanol exposure does not alter blood-brain barrier permeability to sucrose in rats. The blood-brain barrier remains intact even at anesthetic blood ethanol concentrations.

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    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • The blood-brain barrier (BBB) protects the central nervous system but its permeability can be affected by various factors.
    • Understanding BBB permeability is crucial for drug delivery and studying neurological conditions.

    Purpose of the Study:

    • To accurately measure blood-brain barrier permeability to [14C]sucrose.
    • To investigate the effect of ethanol (acute and chronic) on blood-brain barrier permeability.
    • To validate a novel technique for measuring BBB permeability independent of blood flow.

    Main Methods:

    • Utilized a technique measuring [14C]sucrose permeability, independent of blood flow.
    • Compared BBB permeability in rats under urethane or pentobarbitone anesthesia.
    • Assessed BBB permeability in rats with chronic ethanol consumption, acute anesthetic ethanol dose, or both.

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  • Employed positive controls via internal carotid artery ethanol injection to confirm technique sensitivity.

    • Main Results:

    • Urethane anesthesia showed slightly lower [14C]sucrose permeability compared to pentobarbitone, indicating urethane's suitability for BBB studies.
    • No statistically significant differences in BBB permeability to sucrose were observed in rats exposed to chronic ethanol, acute anesthetic ethanol, or combined exposures.
    • Positive controls confirmed the technique's sensitivity to BBB alterations.

    Conclusions:

    • The employed technique is suitable and sensitive for measuring blood-brain barrier permeability.
    • Ethanol, at both chronic consumption levels and acute anesthetic doses, does not significantly alter blood-brain barrier permeability to sucrose.