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Related Experiment Videos

Naloxone epileptogenesis in monkeys

E W Snyder, R E Dustman, C Schlehuber

    The Journal of Pharmacology and Experimental Therapeutics
    |May 1, 1981
    PubMed
    Summary

    Naloxone, an opiate antagonist, can induce electroencephalogram (EEG) seizure activity in monkeys at high doses. Lower doses also alter EEG patterns, suggesting dose-dependent neurological effects.

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    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Naloxone is used clinically to reverse opiate effects.
    • There are concerns regarding naloxone's potential epileptogenic properties.

    Purpose of the Study:

    • To investigate the electroencephalographic (EEG) effects of various naloxone doses.
    • To understand the dose-dependent neurological impact of naloxone.

    Main Methods:

    • Recorded electrographic activity from epidural electrodes in eight monkeys.
    • Performed visual inspection and power spectral analyses of EEG data.
    • Analyzed concurrent visual evoked potentials.

    Main Results:

    • High-dose naloxone ( > 32.0 mg/kg) reliably induced cortical seizure activity.
    • Lower doses ( >= 8.0 mg/kg) increased high-frequency EEG voltage and spiking.
    • Visual evoked potential latencies were consistently extended.
    • EEG changes were time- and dose-dependent, with early high-dose effects mimicking maximal low-dose effects.

    Conclusions:

    • Seizures induced by high-dose naloxone (48.0-64.0 mg/kg) stem from changes observable at clinically relevant doses.
    • These dose-dependent neurological alterations may not be obvious upon routine visual EEG inspection.

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