Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cooling the burn wound to maintain microcirculation

T J Raine, J P Heggers, M C Robson

    The Journal of Trauma
    |May 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Psychostimulant withdrawal: natural history and options for intervention.

    Acta neuropsychiatrica·2016
    Same author

    A case series exploring possible predictors and mechanisms of change in hearing voices groups.

    Psychology and psychotherapy·2014
    Same author

    Owner's perception of carboplatin in conjunction with other palliative treatments for cancer therapy.

    The Journal of small animal practice·2010
    Same author

    Social dysfunction predicts two years clinical outcome in people at ultra high risk for psychosis.

    Journal of psychiatric research·2009
    Same author

    The use of amnion-derived cellular cytokine solution to improve healing in acute and chronic wound models.

    Eplasty·2008
    Same author

    Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity.

    Journal of burns and wounds·2007

    Early cooling of burn wounds improves microvascular circulation and healing. Prompt cold water treatment (within 30 minutes) significantly enhances burn recovery compared to delayed treatment.

    Area of Science:

    • Burn wound healing
    • Dermal microcirculation
    • Therapeutic hypothermia

    Background:

    • Burn injuries cause significant damage to dermal microvascular circulation.
    • The effectiveness of immediate cooling on burn wound outcomes requires further investigation.

    Purpose of the Study:

    • To evaluate the impact of cooling timing on dermal microvascular patency and healing in burn wounds.
    • To determine the optimal window for cold water treatment in partial-thickness burns.

    Main Methods:

    • Standardized scald burns were induced in guinea pigs (10% BSA).
    • Burned areas were cooled with an ice-water bath (0-3°C) for 30 minutes at varying intervals post-burn (10, 20, 30, 60 minutes).
    • Dermal vessel patency was assessed using India-ink perfusion and 133Xe dermal washout studies at multiple time points.

    Related Experiment Videos

    Main Results:

    • Cooling within 10, 20, or 30 minutes post-burn significantly improved dermal perfusion by 96 hours compared to controls.
    • Delayed cooling (60 minutes) showed no significant difference in perfusion compared to untreated controls.
    • Gross examination revealed markedly better healing in wounds cooled within 30 minutes.

    Conclusions:

    • Early application of cold water treatment (within 30 minutes) is crucial for preserving dermal microvascular circulation.
    • Prompt cooling significantly enhances the healing process of partial-thickness burn wounds.
    • These experimental findings support the clinical use of early cold water immersion for burn management.