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Related Experiment Videos

Positional signal transmission in the developing chick limb

L S Honig

    Nature
    |May 7, 1981
    PubMed
    Summary
    This summary is machine-generated.

    A polarizing region in chick wing buds signals limb development. This signal can travel through adjacent leg bud tissue over significant distances, supporting a long-range signaling model for embryonic limb patterning.

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    Area of Science:

    • Developmental biology
    • Embryology
    • Cell signaling

    Background:

    • Limb development relies on patterning along the antero-posterior axis.
    • A polarizing region in chick limb buds is hypothesized to produce a diffusible morphogen.
    • Previous research lacked direct evidence for long-range signaling, with some suggesting local interactions suffice.

    Purpose of the Study:

    • To investigate the transmission range of the signaling molecule from the polarizing region.
    • To provide direct evidence for long-range signaling in chick wing bud development.

    Main Methods:

    • Grafting experiments were performed on embryonic chick wing buds.
    • Leg bud responding tissue was grafted adjacent to a polarizing region graft.
    • The capacity of the polarizing region's signal to transmit through intervening tissue was assessed.

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    Main Results:

    • The polarizing region's pattern signal was transmitted through grafted leg bud tissue.
    • Signal transmission occurred over distances of tens of cell diameters.
    • This supports the existence of a long-range signaling mechanism.

    Conclusions:

    • The polarizing region of the chick wing bud emits a signal that can travel over considerable distances.
    • This finding provides direct evidence for long-range signaling in embryonic limb development.
    • The results challenge models relying solely on local cell-to-cell interactions for pattern formation.