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Extracapsular cataract extraction and pseudophakos implantation in primates: a clinico-pathologic study
Ophthalmic Surgery
|January 1, 1981
Summary
This study evaluated three intraocular lens types in monkeys, finding posterior capsule opacification and varied tissue interactions. Careful implantation and removal are crucial for optimal outcomes.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Veterinary Medicine
Background:
- Cataract surgery often involves intraocular lens (IOL) implantation.
- Long-term biocompatibility and tissue interactions of different IOL designs require thorough investigation.
Purpose of the Study:
- To histologically and clinically compare the long-term effects of three IOL types: Choyce Mark VIII, Binkhorst iridocapsular, and Shearing posterior chamber lenses.
- To evaluate the biological response to IOL implantation in a primate model.
Main Methods:
- Eighteen rhesus monkeys received one of the three IOL types.
- Eyes were examined clinically and histologically 4-28 months post-implantation.
- Control eyes included unoperated eyes and those with lens extraction only.
Main Results:
- Posterior capsule opacification was linked to lens epithelial cell metaplasia, particularly when exposed to aqueous humor.
- Binkhorst lenses showed iris pigment epithelium changes; Choyce lenses caused iris root thinning and occasional inflammation.
- Shearing lens loops eroded the ciliary body when not properly seated in the capsular bag.
Conclusions:
- All tested IOLs were clinically well-tolerated, but histological differences were observed.
- Proper IOL loop placement within the capsular envelope is critical to avoid ciliary body erosion.
- Surgical technique for both implantation and removal should account for potential intraocular tissue interactions.