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Mercury/selenium interaction. A comparative study on pigs

J C Hansen, P Kristensen, S N Al-Masri

    Nordisk Veterinaermedicin
    |February 1, 1981
    PubMed
    Summary
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    Selenium (Na275SeO3) forms a protective complex with inorganic mercury (203HgCl2), reducing mercury toxicity in pigs. This mercury-selenium complex is biologically inactive and stored in organs like the liver and spleen.

    Area of Science:

    • Toxicology
    • Biochemistry
    • Comparative Medicine

    Background:

    • Inorganic mercury is a potent toxin with significant health implications.
    • Selenium is known to modulate mercury toxicity, but the exact mechanisms and cross-species applicability require further investigation.
    • Understanding mercury-selenium interactions is crucial for developing effective detoxification strategies.

    Purpose of the Study:

    • To investigate the interaction between inorganic mercury and selenium in a pilot study using pigs.
    • To confirm if the mercury-selenium interaction observed in mice is qualitatively similar in pigs.
    • To elucidate the mechanism of selenium's protective effect against mercury toxicity.

    Main Methods:

    • A pilot experiment involving three pigs.

    Related Experiment Videos

  • Single intraperitoneal injections of inorganic mercury (203HgCl2) and selenium (Na275SeO3).
  • Qualitative analysis of the interaction between mercury and selenium.

    • Main Results:

    • The interaction between inorganic mercury and selenium in pigs was found to be qualitatively uniform compared to mice.
    • Selenium appears to detoxify mercury by forming a biologically inactive complex.
    • This mercury-selenium complex is formed in an equimolar ratio.
    • The complex cannot cross biological barriers such as the placenta and choroid plexus.
    • The complex is primarily stored in the liver and spleen.

    Conclusions:

    • The findings confirm a conserved mechanism of mercury-selenium interaction across species (mice and pigs).
    • Selenium's detoxification of mercury involves the formation of an equimolar, biologically inactive complex.
    • This complex's inability to cross biological barriers limits systemic distribution and suggests targeted organ accumulation.