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[A new method to evaluate myocardial preservation techniques (author's transl)]

P Menasché, A Piwnica, J S Ingwall

    La Nouvelle Presse Medicale
    |February 7, 1981
    PubMed
    Summary

    Nuclear magnetic resonance (NMR) using 31Phosphorus allows sequential monitoring of high-energy phosphates and intracellular pH. This technique is valuable for assessing myocardial preservation during ischemia and reperfusion.

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    Area of Science:

    • Biophysics
    • Biochemistry
    • Cardiology

    Context:

    • Nuclear Magnetic Resonance (NMR) is a non-invasive imaging technique.
    • 31Phosphorus NMR spectroscopy enables real-time biochemical analysis.
    • Whole-heart NMR applications allow simultaneous biochemical and hemodynamic data acquisition.

    Purpose:

    • To evaluate the utility of 31Phosphorus NMR spectroscopy for assessing myocardial preservation.
    • To demonstrate the value of NMR in monitoring tissue energetics during ischemia and reperfusion.

    Summary:

    • 31Phosphorus NMR spectroscopy provides sequential measurements of high-energy phosphate compounds and intracellular pH in tissues.
    • The technique can be applied to the whole heart, enabling simultaneous recording of biochemical and hemodynamic data.

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  • Case studies highlight NMR's effectiveness in evaluating myocardial preservation strategies during ischemic and reperfusion events.

    • Impact:

    • NMR offers a novel, non-invasive approach for evaluating the efficacy of myocardial preservation techniques.
    • This technology aids in optimizing cardiac surgical procedures and post-operative care.
    • NMR facilitates a deeper understanding of cardiac metabolism under stress conditions.