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[Gluten enteropathy in children from south-eastern France (author's transl)]

P Chapoy, F Elbaz, R Bernard

    La Nouvelle Presse Medicale
    |February 7, 1981
    PubMed

    Insights

    Gluten-induced enteropathy, diagnosed in 123 children in France, shows varied symptoms by age. Dietary changes improve clinical signs, but mucosal healing and sustained gluten avoidance are crucial for recovery.

    Area of Science:

    • Pediatric Gastroenterology
    • Clinical Nutrition

    Context:

    • Gluten-induced enteropathy (celiac disease) incidence and presentation in a French cohort (1969-1979).
    • Analysis of demographic factors including age, sex, and ethnicity.
    • Comparison of clinical manifestations between younger and older children.

    Purpose:

    • To estimate the incidence of gluten-induced enteropathy in south-eastern France.
    • To describe the clinical features and diagnostic characteristics of the disease in children.
    • To evaluate the impact of dietary gluten withdrawal and reintroduction on clinical and histological outcomes.

    Summary:

    • 123 cases diagnosed, with an incidence of 1:4,600 births. Mean age 3.2 years, with a predominance of girls and North-Africans.
    • Younger children (<2 years) presented with malabsorption, while older children (>2 years) primarily showed growth retardation.
    • Dietary gluten withdrawal led to rapid clinical improvement, but mucosal healing averaged 19 months. Gluten reintroduction caused histological relapse in a subset of patients.

    Impact:

    • Highlights the importance of early diagnosis and dietary management in pediatric gluten-induced enteropathy.
    • Suggests a potential increase in diagnosed cases due to reduced gluten in infant foods.
    • Underscores the long-term implications of gluten exposure and the challenges in assessing transient intolerances.

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