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Sustained decrease in fat consumption produced by amphetamine in rats maintained on a dietary self-selection regime

R B Kanarek, L Ho, R G Meade

    Pharmacology, Biochemistry, and Behavior
    |April 1, 1981
    PubMed
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    D-amphetamine sulfate reduced total caloric intake in rats. However, it selectively suppressed fat consumption over protein and carbohydrate intake, indicating a specific drug effect on macronutrient preference.

    Area of Science:

    • Neuroscience
    • Nutritional Science
    • Pharmacology

    Background:

    • Appetite regulation is complex, involving hormonal and neural pathways.
    • Understanding how anorectic drugs affect macronutrient selection is crucial for appetite research.

    Purpose of the Study:

    • To investigate the effects of d-amphetamine sulfate on caloric intake and macronutrient self-selection in female rats.
    • To determine if amphetamine's effect on fat consumption is a general property of appetite-suppressing drugs.

    Main Methods:

    • Female rats were administered anorectic doses of d-amphetamine sulfate (0.5, 1.0, 2.0 mg/kg).
    • Animals had access to a self-selection diet (protein, fat, carbohydrate) for six hours daily.
    • Food intake was measured at two and six hours post-injection.

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    Main Results:

    • Amphetamine caused dose-related decreases in total caloric intake, irrespective of diet type.
    • Protein and carbohydrate intake were suppressed initially but recovered within six hours.
    • Fat intake was suppressed throughout the entire six-hour feeding period at all tested doses.

    Conclusions:

    • D-amphetamine sulfate selectively suppresses fat intake in rats, independent of its effect on overall caloric reduction.
    • This selective effect on fat consumption is not a universal characteristic of all appetite-reducing drugs.