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[Underdosing and overdosing with digitalis]

T Hess

    Schweizerische Medizinische Wochenschrift
    |March 28, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Digitalis dosage errors are common due to narrow therapeutic ranges and patient factors. Understanding guidelines for digoxin and digitoxin is crucial for safe cardiac glycoside use.

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    Area of Science:

    • Pharmacology
    • Clinical Therapeutics

    Context:

    • Cardiac glycosides, such as digoxin and digitoxin, have a narrow therapeutic index.
    • Frequent digitalis dosage errors stem from patient noncompliance and fluctuating requirements.

    Purpose:

    • To review guidelines for optimizing digoxin and digitoxin dosage.
    • To discuss factors influencing digitalis requirements and management strategies.

    Summary:

    • Common causes of digitalis dosage errors include relative over- or underdosage, patient noncompliance, and changing patient needs.
    • Key factors influencing dosage include renal failure, liver and gastrointestinal diseases, body weight, age, electrolyte imbalances, hypoxia, thyroid dysfunction, and drug interactions.
    • The review covers symptoms, signs, and treatment of both underdigitalization and digitalis intoxication.

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    Impact:

    • Improved understanding of digitalis dosing can reduce medication errors.
    • This review aids clinicians in managing cardiac glycoside therapy safely and effectively.
    • Highlights the importance of individualized dosing and patient education in preventing digitalis toxicity.