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Related Experiment Videos

Physical dependence on morphine fails to develop during the hibernating state

A L Beckman, C Llados-Eckman, T L Stanton

    Science (New York, N.Y.)
    |June 26, 1981
    PubMed
    Summary

    Mammalian hibernators, Citellus lateralis, develop physical dependence on morphine when active, but not during hibernation. Opioid exposure during hibernation shows partial central nervous system responsiveness.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Mammalian Hibernation

    Background:

    • Physical dependence on opioids is a significant clinical concern.
    • Mammalian hibernation represents a unique physiological state with altered metabolic and neurological functions.
    • Understanding opioid interactions during hibernation is crucial for potential therapeutic applications.

    Purpose of the Study:

    • To investigate the development of physical dependence on morphine in the mammalian hibernator, Citellus lateralis.
    • To determine if morphine exposure during hibernation affects the development of physical dependence.
    • To assess the central nervous system's responsiveness to opioids during the hibernating state.

    Main Methods:

    • Morphine administration to active and hibernating Citellus lateralis.

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  • Assessment of physical dependence using standard pharmacological criteria.
  • Observation of behavioral responses to morphine during hibernation.

    • Main Results:

    • Physical dependence on morphine developed typically in active Citellus lateralis.
    • No physical dependence on morphine was observed when exposure was limited to the hibernating state.
    • Morphine administration during hibernation induced stereotyped behaviors, indicating partial central nervous system opioid responsiveness.

    Conclusions:

    • The hibernating state in Citellus lateralis prevents the typical development of morphine physical dependence.
    • The central nervous system retains partial responsiveness to opioids during hibernation.
    • Hibernation significantly alters opioid pharmacodynamics and dependence liability.