An analysis of quantitative relationships of granulocyte transfusion therapy in canines

Granulocyte transfusions were administered to dogs rendered neutropenic by prior cyclophosphamide treatment. Linear regression analysis established significant direct relationships between numbers of granulocytes infused per kg body weight and blood increment achieved. Migration of granulocytes to cerebrospinal fluid during induced Candida albicans meningitis related to concurrent increments in blood following transfusion. Levels of C. albicans systemic infection were inversely related to numbers of granulocytes administered during a four-day course of therapy. These studies demonstrate the quantitative relationships of granulocyte transfusion therapy to potential therapeutic effects at the tissue level.