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Related Experiment Videos

Epithelial-stromal interface in normal and neoplastic human bladder epithelium

J Alroy, V E Gould

    Ultrastructural Pathology
    |April 1, 1980
    PubMed
    Summary

    Invasive bladder cancer shows altered epithelial-stromal interfaces, with reduced basal lamina and hemidesmosomes. These changes, including increased lysosomes and filaments, may predict invasiveness.

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    Area of Science:

    • Urology
    • Oncology
    • Cell Biology

    Background:

    • The epithelial-stromal interface is crucial for tissue integrity and cancer progression.
    • Understanding ultrastructural changes in bladder cancer can aid in predicting invasiveness.

    Purpose of the Study:

    • To investigate the ultrastructural differences at the epithelial-stromal interface in various bladder pathologies.
    • To identify potential ultrastructural markers of invasiveness in transitional cell carcinoma.

    Main Methods:

    • Transmission electron microscopy was used to examine biopsy specimens.
    • Specimens included normal controls, inverted papilloma, noninvasive papillary carcinoma, and invasive transitional cell carcinoma.

    Main Results:

    • Invasive transitional cell carcinomas exhibited attenuated/absent basal lamina and fewer hemidesmosomes.
    • Neoplastic cells showed increased lysosomes (some in exocytosis) and cytoplasmic filaments at the invasive pole.
    • Tight junctions were present at the tumor-stromal interface in invasive cancers.
    • These features were absent in normal epithelium, papilloma, and noninvasive carcinomas.

    Conclusions:

    • Ultrastructural alterations at the epithelial-stromal interface are specific to invasive bladder cancer.
    • These changes may serve as important parameters for evaluating bladder carcinoma invasiveness.

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