[Clinical pathophysiology and intensive therapy of diffuse peritonitis]

Area of Science:

• Critical Care Medicine
• Surgical Pathology
• Pharmacology

Background:

• Diffuse peritonitis presents complex pathophysiological challenges.
• Management requires addressing protein and electrolyte imbalances, and acute respiratory distress.

Purpose of the Study:

• To investigate pathophysiological shifts in diffuse peritonitis.
• To evaluate methods for correcting these shifts and associated complications.
• To study cephalosporin pharmacodynamics and pharmacokinetics in this context.

Main Methods:

• Investigated 204 patients with diffuse peritonitis.
• Analyzed protein and water-electrolyte disorders, and acute respiratory insufficiency.
• Evaluated intravenous and intra-oral cephalosporin properties.
• Used antibiotics as indicators to assess blood mixing and shunting.

Main Results:

• Identified key pathophysiological shifts requiring correction.
• Demonstrated disturbances in blood mixing and shunting using antibiotic indicators.
• Characterized cephalosporin pharmacodynamics and pharmacokinetics.

Conclusions:

• Patients with diffuse peritonitis require intensive therapy.
• A 5-12 day intensive care unit stay is advised for management.
• Understanding pharmacokinetics is crucial for antibiotic therapy in peritonitis.