[Therapeutic results in lymphogranulomatosis and their relationship to immunological reactivity]

The efficacy of two treatment modalities of Hodgkin's disease stages I-IV (1) local irradiation of COPP chemotherapy with protracted low-dosage cyclophosphamide administration, or (2) all-round irradiation of lymphatic vessels or the same COPP treatment combined with shock doses of cyclophosphamide is evaluated. Duration of the first remission and survival time were followed in 45 patients in 1969-1978. During remission, some patients received a non-specific immunotherapy (BCG vaccination). The cumulative index of the first remission appeared to increase from 19 to 72% (radiation therapy) and from 14 to 68% (chemotherapy) within 3 years in the case of the second modality. The survival time of patients did not differ significantly in both study groups. Remission was longer in patients who had received BCG vaccination.