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Antimicrobial agent-associated colitis and diarrhea

W L George

    The Western Journal of Medicine
    |August 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Clostridium difficile toxin causes most antibiotic-associated colitis and diarrhea. Vancomycin effectively treats this condition, though relapses can occur, and further research is needed.

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    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Microbiology

    Background:

    • Antimicrobial agent-associated colitis is a recognized clinical condition.
    • The specific causative agent has only recently been identified.

    Purpose of the Study:

    • To identify the cause of antimicrobial agent-associated colitis and diarrhea.
    • To discuss the treatment and implications of this discovery.

    Main Methods:

    • Cultivation of Clostridium difficile from fecal samples.
    • Detection of Clostridium difficile toxin.

    Main Results:

    • Clostridium difficile toxin is the cause of most pseudomembranous colitis and some nonspecific colitis or diarrhea associated with antimicrobial agents.

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  • Oral vancomycin is an effective treatment for Clostridium difficile-induced colitis, with some cases of relapse reported.

    • Conclusions:

    • Clostridium difficile is a significant intestinal pathogen causing antibiotic-associated gastrointestinal issues.
    • Further research is required to understand the epidemiology, pathogenesis, and prevention of Clostridium difficile toxin-induced diarrhea.