[Urinary total estrogens in normal menstrual cycle and early pregnancy (author's transl)]

A ratio of urinary total estrogens to creatinine (E/C, micrograms/g) was measured in every morning through the cycle in normal menstruating cycling women and during her early pregnancy. The level of follicular phase was 17.7 +/- 5.4 micrograms/g, ovulatory phase 78.8 +/- 8.8 micrograms/g and luteal phase 26.7 +/- 11.2 micrograms/g. In the spontaneous pregnancies E/C levels elevated sharply after 15 weeks of gestation. In the pregnancy after induced ovulation with clomifene citrate and conjugated estrogens, E/C levels were decreased from 7 days prior to the initiation of genital bleeding of spontaneous abortion. The need for multiple determinations over considerable periods of time is solved by our methods of easily repeated sequential measurements of urinary total estrogens estimated by E/C ratio.