Neutrophil chemotactic defect and hypogammaglobulinemia

A 15-months-old boy developed agranulocytosis after administration of Chloramphenicol and Aminopyrine. In spite of total hematological recovery, the patient's immunological study disclosed a persistent neutrophil chemotactic defect and hypogammaglobulinemia. Other studies of specific and non-specific immunity were normal. Neutrophil adherence, random and random stimulated mobility were always within the normal range. The presence of chemotactic inhibitors was discarded. In vitro incubation of his neutrophils with Cytochalasin B at 0.1 micrograms/ml final concentration, reversed the chemotactic abnormality suggesting a possible cell membrane defect.