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Rectal administration of theophylline in aqueous solution
Acta Paediatrica Scandinavica
|March 1, 1981
Summary
Rectal administration of theophylline in children achieved therapeutic serum levels comparable to intravenous infusion. This method offers a simple, effective alternative, even with nausea or vomiting, pending further research.
Area of Science:
- Pediatric Pharmacology
- Gastroenterology
Background:
- Theophylline, used for respiratory conditions, has a narrow therapeutic index, making administration challenging.
- Intravenous (IV) administration typically requires 20 minutes to reach safe and effective serum levels.
Purpose of the Study:
- To evaluate the efficacy and safety of rectal theophylline administration in children.
- To compare serum theophylline levels achieved via rectal versus intravenous routes.
Main Methods:
- Twenty children received a single rectal dose of theophylline in an aqueous solution.
- Serum theophylline concentrations were monitored post-administration.
Main Results:
- Rectal administration yielded serum theophylline levels equivalent to a 20-minute IV infusion.
- No adverse effects were observed during the study.
- Variations in peak serum levels were consistent with those seen after IV administration.
Conclusions:
- Rectal administration of aqueous theophylline is a potential alternative to IV infusion in pediatric patients.
- This method is simple, suitable for home use, and accommodates conditions like nausea and vomiting.
- Further investigations are necessary before widespread recommendation.