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Perinatal Campylobacter fetus ss jejuni enteritis
Acta Paediatrica Scandinavica
|March 1, 1981
Insights
A newborn infant experienced Campylobacter jejuni-associated diarrhea, likely transmitted from his mother. Both mother and infant mounted significant antibody responses to the bacteria, confirming infection.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Immunology
Background:
- Campylobacter jejuni is a leading cause of bacterial gastroenteritis worldwide.
- Neonatal infections with Campylobacter jejuni are rare but can be severe.
- Understanding transmission routes and host immune responses is crucial for prevention and treatment.
Observation:
- A 2-day-old breast-fed infant presented with mucoid and bloody diarrhea.
- Campylobacter fetus subspecies jejuni was isolated from the infant's stool but not blood.
- The infant's mother experienced similar symptoms one day prior, suggesting a transmission source.
Findings:
- The infant's illness was attributed to Campylobacter jejuni infection, likely acquired from his mother.
- Both the infant and mother demonstrated specific IgM, IgG, and IgA antibody responses to Campylobacter jejuni.
- Enzyme-linked immunosorbent assay (ELISA) confirmed the antibody responses to both autologous and reciprocal bacterial strains.
Implications:
- This case highlights the potential for mother-to-infant transmission of Campylobacter jejuni.
- The study demonstrates an active immune response in both mother and neonate to Campylobacter jejuni infection.
- Further research into neonatal Campylobacter jejuni infections and associated immune responses is warranted.
Abstract:
A 2-day-old breast-fed male infant developed mucoid and blood diarrhoea, and Campylobacter fetus ss jejuni was isolated from the stools but not from the blood. The probable source of transmission was his mother in whom symptoms of Campylobacter jejuni-associated illness began one day earlier. Both showed IgM, IgG and IgA antibody responses to autologous and reciprocal strains of Campylobacter jejuni as studied by ELISA.