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The acute pretrigeminal rat

C Gottesmann, P User, B Zernicki

    Acta Neurobiologiae Experimentalis
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Researchers transected the brainstems of five rats, creating pretrigeminal rats. The isolated cerebrum demonstrated signs of wakefulness, indicated by EEG activity and hippocampal theta waves, suggesting preserved consciousness.

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    Area of Science:

    • Neuroscience
    • Physiology
    • Animal Models

    Background:

    • The pretrigeminal transection model in cats has been instrumental in studying isolated forebrain function.
    • Understanding the state of consciousness in animals with severe brainstem lesions is crucial for neurological research.

    Purpose of the Study:

    • To investigate the state of wakefulness and cortical activity in pretrigeminal rats.
    • To determine if sensory and hypothalamic stimulation can modulate EEG activity in the isolated cerebrum.

    Main Methods:

    • Brainstem transection at the pretrigeminal level in five rats.
    • Electrocorticography (EEG) recording from the frontal cortex.
    • Hippocampal EEG recording to analyze theta activity.
    • Application of olfactory, visual, and hypothalamic electrical stimulation.

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    Main Results:

    • Dominance of desynchronized EEG activity in the frontal cortex.
    • Continuous presence of low-frequency theta activity (approx. 4 Hz) in the dorsal hippocampus.
    • Olfactory and hypothalamic stimulation increased cortical desynchronization and hippocampal theta regularity/frequency.
    • Visual stimuli were effective in only three out of five rats; no ocular responses were observed.

    Conclusions:

    • The isolated cerebrum in pretrigeminal rats exhibits EEG patterns indicative of wakefulness.
    • Sensory and hypothalamic inputs can modulate cortical and hippocampal activity in this preparation.
    • The pretrigeminal rat serves as a viable model for studying the isolated cerebrum's state, similar to the pretrigeminal cat.