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Related Experiment Videos

Plasma lipids in tropical sprue

C Tiruppathi, P G Hill, V I Mathan

    The American Journal of Clinical Nutrition
    |June 1, 1981
    PubMed
    Summary

    Patients with tropical sprue show signs of essential fatty acid depletion, including lower linoleic acid levels. However, this depletion is unlikely to cause the observed triglyceride accumulation in the intestinal mucosa.

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    Area of Science:

    • Gastroenterology
    • Nutritional Science
    • Biochemistry

    Background:

    • Tropical sprue is associated with intestinal mucosal triglyceride accumulation.
    • Potential causes include essential fatty acid deficiency due to steatorrhea and low linoleic acid intake.

    Purpose of the Study:

    • To investigate plasma lipid profiles in tropical sprue patients.
    • To compare lipid levels with healthy rural controls.
    • To assess the role of essential fatty acids in the disease pathology.

    Main Methods:

    • Analysis of plasma lipids in patients with tropical sprue and healthy controls.
    • Quantification of fatty acids, including linoleic acid and eicosatrienoic acid.
    • Comparison of lipid profiles between the two groups.

    Main Results:

    • Tropical sprue patients exhibited decreased plasma linoleic acid levels.
    • Elevated monoenoic fatty acids and the presence of 5,8,11-eicosatrienoic acid were noted in the lecithin fraction.
    • Healthy controls maintained adequate arachidonic acid levels and repressed eicosatrienoic acid formation.

    Conclusions:

    • Observations suggest essential fatty acid depletion in tropical sprue patients.
    • Unequivocal evidence of essential fatty acid deficiency was not found.
    • The observed essential fatty acid depletion is unlikely to be the primary cause of mucosal triglyceride accumulation in tropical sprue.

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