Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Gastric Motility01:16

Gastric Motility

Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrections.

International journal of spine surgery·2026
Same author

Effects of ibudilast on oxycodone-induced analgesia and subjective effects in opioid-dependent volunteers.

Drug and alcohol dependence·2017
Same author

Potential biomarkers associated with discrimination between latent and active pulmonary tuberculosis.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2017
Same author

Synthesis and biological evaluation of 2,6-di(furan-3-yl)anthracene-9, 10-dione as an inhibitor of human protein kinase CK2.

Die Pharmazie·2016
Same author

Chromosome number and DNA content of tobacco cells adapted to NaCl.

Plant cell reports·2013
Same author

Living kidney donor transplants over a 16-year period in South Africa: a single center experience.

Annals of African medicine·2011
Same journal

Correction to I.M. Matters News: Sleep medicine for seniors.

Annals of internal medicine·2026
Same journal

Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone : A Target Trial Emulation.

Annals of internal medicine·2026
Same journal

Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-Like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Methodological Approaches to Real-World Evidence Generation for Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Weekly and Biweekly Treatment With Bofanglutide Versus Semaglutide in Chinese Patients With Type 2 Diabetes : A Phase 2b Randomized Clinical Trial.

Annals of internal medicine·2026
Same journal

Grappling with GLP-1 prescribing.

Annals of internal medicine·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

Gastrointestinal Motility Monitor (GIMM)
08:15

Gastrointestinal Motility Monitor (GIMM)

Published on: December 2, 2010

Abnormal colonic motility in progressive systemic sclerosis

W M Battle, W J Snape, S Wright

    Annals of Internal Medicine
    |June 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Progressive systemic sclerosis impairs gastrocolonic response early. Severe disease leads to smooth muscle atrophy and severe colonic motor disturbances, impacting patient outcomes.

    More Related Videos

    Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines
    12:00

    Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines

    Published on: January 28, 2016

    Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
    07:41

    Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

    Published on: February 3, 2016

    Related Experiment Videos

    Last Updated: May 11, 2026

    Gastrointestinal Motility Monitor (GIMM)
    08:15

    Gastrointestinal Motility Monitor (GIMM)

    Published on: December 2, 2010

    Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines
    12:00

    Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines

    Published on: January 28, 2016

    Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
    07:41

    Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

    Published on: February 3, 2016

    Area of Science:

    • Gastroenterology
    • Internal Medicine
    • Pathophysiology

    Background:

    • Progressive systemic sclerosis (PSS) is a connective tissue disease known to affect gastrointestinal (GI) smooth muscle function.
    • GI dysmotility is a common complication of PSS, impacting patient quality of life and disease progression.

    Purpose of the Study:

    • To investigate the impact of PSS on colonic motility and the gastrocolonic response.
    • To assess the effects of pharmacological agents (neostigmine and metoclopramide) on colonic activity in PSS patients.
    • To correlate colonic motor disturbances with disease severity and patient outcomes.

    Main Methods:

    • Assessed colonic spike and contractile activity in 10 PSS patients and normal subjects.
    • Stimulated motility using a 1000-kcal meal, neostigmine, or metoclopramide.
    • Grouped patients into Group I (less severe PSS) and Group II (severe PSS) based on systemic manifestations.
    • Examined colonic smooth muscle histology in deceased patients.

    Main Results:

    • Normal subjects showed increased colonic motility after a meal; 90% of PSS patients did not.
    • Neostigmine and metoclopramide stimulated colonic motility in normal subjects and in 40% of Group I PSS patients.
    • Pharmacological agents had no effect on colonic motility in Group II (severe PSS) patients.
    • Severe PSS patients exhibited significant GI abnormalities and organ dysfunction; smooth muscle atrophy was noted in fatal cases.

    Conclusions:

    • The gastrocolonic response is diminished early in PSS.
    • Progressive smooth muscle atrophy in severe PSS contributes to significant colonic motor dysfunction.
    • Colonic motor disturbances are linked to disease severity and poor prognosis in PSS.