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[Osteonecrosis in drepanocytemia (author's transl)]
Medecine Tropicale : Revue Du Corps De Sante Colonial
|March 1, 1978
Summary
Aseptic osteonecrosis, linked to sickling, affects 8.5% of heterozygotic and 0.2% of homozygotic sickle cell patients. This condition, particularly common in SC disease, is influenced by factors like alcoholism and cortisone use.
Area of Science:
- Hematology
- Orthopedics
- Vascular Biology
Context:
- Aseptic osteonecrosis is a known complication of sickle cell disease.
- Understanding its prevalence and risk factors is crucial for patient management.
- Vascular complications, particularly affecting the femoral epiphyses, are a primary concern.
Purpose:
- To detail the incidence of aseptic osteonecrosis in sickle cell disease (SCD) patients in the USA.
- To identify predisposing factors and common sites of osteonecrosis.
- To describe the radiological characteristics of this condition.
Summary:
- Aseptic osteonecrosis in SCD results from local hypoxemia due to the sickling process.
- Incidence rates are 8.5% for heterozygotic and 0.2% for homozygotic SCD patients in the USA.
- It is infrequent in sickle cell trait (AS) but common in sickle cell-hemoglobin C disease (SC).
- Facilitating factors include alcoholism, hyperlipidemia, hyperuricemia, corticosteroid therapy, and pregnancy.
- Femoral epiphyses are frequently affected by vascular causes.
- Radiological features are presented for diagnostic purposes.
Impact:
- Provides essential epidemiological data on aseptic osteonecrosis in sickle cell disease.
- Highlights key risk factors for clinicians to consider in at-risk populations.
- Aids in the radiological diagnosis and understanding of osteonecrosis in SCD.
- Informs clinical practice regarding the prevention and management of bone complications in sickle cell disorders.