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[Morphological determinism]

A I Strukov, V P Petlenko, O K Khmel'nitskiĭ

    Arkhiv Patologii
    |January 1, 1981
    PubMed
    Summary

    Morphological determinism explains how an organism

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    Area of Science:

    • Pathology and medical science.
    • Integrative biology and physiology.

    Context:

    • Historically, pathology linked structural-morphological and causal concepts.
    • Morphological determinism integrates host structure and environmental interactions.

    Purpose:

    • To establish morphological determinism as a core concept in pathology.
    • To re-evaluate the relationship between structure and function in disease.

    Summary:

    • Morphological determinism posits that universal structural associations within an organism dictate its responses to environmental factors.
    • It emphasizes the unity of structure (morphology) and function (dynamics) in pathological processes.
    • Functional changes are underpinned by synchronous structural-morphological equivalents, refuting the primacy of functional over structural changes.

    Impact:

    • Provides a framework for understanding organismal integrity and organization.
    • Reorients medical professionals to identify the morphological basis of all pathological and functional changes, down to the molecular level.
    • Challenges the concept of "functional diseases" by grounding all pathology in structural alterations.

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