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The prognosis of corticosteroid-responsive individuals
Archives of Ophthalmology (Chicago, Ill. : 1960)
|May 1, 1981
Summary
Individuals genetically predisposed to high intraocular pressure (IOP) response to corticosteroids are more likely to develop ocular hypertension and primary open-angle glaucoma over time.
Area of Science:
- Ophthalmology
- Genetics
- Glaucoma Research
Background:
- Intraocular pressure (IOP) response to topical corticosteroids is genetically influenced.
- Genes affecting corticosteroid responsiveness and primary open-angle glaucoma (POAG) are closely linked.
Purpose of the Study:
- To investigate the long-term relationship between corticosteroid responsiveness and the development of POAG.
- To determine if individuals with high corticosteroid responsiveness are at increased risk for developing elevated IOP and glaucomatous changes.
Main Methods:
- A longitudinal study followed 35 patients with high corticosteroid responsiveness for at least ten years.
- Participants were monitored without therapeutic intervention.
- Intraocular pressure (IOP) and visual field changes were assessed over the follow-up period.
Main Results:
- Sustained IOP elevation (>21 mm Hg) occurred in five of 22 normotensive subjects.
- Two of these subjects developed glaucomatous field defects.
- Seven of 13 subjects with initial ocular hypertension experienced further IOP rise and glaucomatous field changes.
Conclusions:
- High corticosteroid responsiveness is a significant risk factor for developing elevated IOP.
- Corticosteroid-responsive individuals are more prone to developing glaucomatous field defects compared to non-responsive individuals.
- These findings highlight the genetic link between corticosteroid response and POAG development.