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Melioidosis with acute meningoencephalomyelitis in a horse
Abstract:
A case of acute meningoencephalomyelitis caused by infection with Pseudomonas pseudomallei is described. Clinically there was inability to stand, opisthotonus, facial paralysis and nystagmus, rapidly progressing to violent struggling. Gross examination revealed malacia and haemorrhage in the medulla oblongata and adjacent spinal cord. Microscopically there were disseminated focal neutrophilic accumulations in affected areas, perivascular cuffing with mononuclear cells and lymphocytes and marked oedema. Intracellular bacteria were identified in sections stained by the Giemsa method.
Insights
A rare case of acute meningoencephalomyelitis caused by Pseudomonas pseudomallei infection is detailed. The study highlights severe neurological symptoms and pathological findings in the brain and spinal cord.
Area of Science:
- Neurology
- Infectious Diseases
- Pathology
Background:
- Pseudomonas pseudomallei, the causative agent of melioidosis, can lead to severe neurological complications.
- Meningoencephalomyelitis is a serious inflammation of the brain and spinal cord.
Observation:
- A patient presented with acute neurological decline, including inability to stand, opisthotonus, facial paralysis, and nystagmus.
- Clinical progression was rapid, leading to severe struggling.
Findings:
- Gross examination revealed malacia and hemorrhage in the medulla oblongata and spinal cord.
- Microscopic analysis showed focal neutrophilic accumulations, perivascular cuffing, and edema.
- Intracellular bacteria were identified within affected tissues using Giemsa staining.
Implications:
- This case underscores the potential for Pseudomonas pseudomallei to cause severe central nervous system infections.
- Accurate diagnosis and understanding of the neuropathology are crucial for managing melioidosis-related neurological complications.