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[Creatinine in the amniotic fluid]
Creatinine concentration in the amniotic fluid during the latter half of pregnancy was investigated by single determinations in 39 patients and serial determinations in 2 patients. Concentrations of creatinine remained constant or increased very gradually up to approximately 34 weeks, at which point a more abrupt increase apparently took place so that after 37 weeks the level was 1,5 mg. Physiologically, these data lend support to the commonly held theory of fetal urine as an additive source of amniotic fluid. Clinically, they suggest that assay of creatinine might prove useful in estimation of fetal maturity.
Creatinine concentration in the amniotic fluid during the latter half of pregnancy was investigated by single determinations in 39 patients and serial determinations in 2 patients. Concentrations of creatinine remained constant or increased very gradually up to approximately 34 weeks, at which point a more abrupt increase apparently took place so that after 37 weeks the level was 1,5 mg. Physiologically, these data lend support to the commonly held theory of fetal urine as an additive source of amniotic fluid. Clinically, they suggest that assay of creatinine might prove useful in estimation of fetal maturity.