Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydrogen bonding in DNA base complexes

B M Powell, P Martel

    Biophysical Journal
    |May 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    This study analyzes DNA base complex frequencies using interatomic potentials. While 1-methylthymine (1-MT) showed good agreement, cytosine monohydrate (CMH) required considering hydration for accurate modeling.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Assessment of environmental radioactivity in the City of Melilla.

    Scientific reports·2026
    Same author

    [Contribution of technological aids to the extraction of orbital foreign bodies].

    Journal francais d'ophtalmologie·2024
    Same author

    Indoor radon risk mapping of the Canary Islands using a methodology for volcanic islands combining geological information and terrestrial gamma radiation data.

    The Science of the total environment·2024
    Same author

    Crystal structure of a three-tetrad, parallel, K<sup>+</sup>-stabilized human telomeric G-quadruplex at 1.35 Å resolution.

    Acta crystallographica. Section F, Structural biology communications·2023
    Same author

    External validation of the Oldham composite Covid-19 associated mortality model (OCCAM), a prognostic model for death in patients hospitalised with Covid-19.

    Infectious diseases now·2023
    Same author

    Multiparametric analysis for the determination of radon potential areas in buildings on different soils of volcanic origin.

    The Science of the total environment·2023
    Same journal

    Tau protein differentially affects Piezo1 and Kir2.1 channels in brain capillary endothelial cells.

    Biophysical journal·2026
    Same journal

    Emergent Intercellular Junction Stability during Cyclic Tissue Loading.

    Biophysical journal·2026
    Same journal

    Enhanced-Sampling Simulations Reveal Distinct Intermediates in SARS-CoV-2 FSE Pseudoknot Interconversion.

    Biophysical journal·2026
    Same journal

    Structure-based simulations of the full Flock House virus capsid reveal pathways and energetics of an infection-critical peptide externalization event.

    Biophysical journal·2026
    Same journal

    Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

    Biophysical journal·2026
    Same journal

    Anisotropic unbinding and location-dependent hovering of a kinesin motor head over microtubule.

    Biophysical journal·2026
    See all related articles

    Area of Science:

    • Biophysics
    • Computational Chemistry
    • Molecular Dynamics

    Background:

    • DNA base pairing is fundamental to genetic information transfer.
    • Understanding intermolecular interactions is crucial for molecular biology.
    • Experimental frequencies provide insights into DNA base complex dynamics.

    Purpose of the Study:

    • To analyze experimental intermolecular frequencies of DNA base complexes.
    • To evaluate simple analytic interatomic potentials for these complexes.
    • To investigate the role of hydration in cytosine monohydrate (CMH) interactions.

    Main Methods:

    • Analysis of experimental intermolecular frequencies.
    • Application of simple analytic interatomic potentials.
    • Determination of hydrogen bond potentials using two models for nonbonded interactions.

    Related Experiment Videos

    Main Results:

    • Observed frequencies in 1-methylthymine (1-MT) were well-described by the models.
    • Corresponding potentials for 1-MT differed significantly between the two models.
    • Observed frequencies in CMH were less accurately described, despite similar hydrogen bond potentials.
    • Hydration interactions were identified as significant for CMH.

    Conclusions:

    • Simple analytic potentials can describe some DNA base complex dynamics.
    • Model-dependent potentials highlight limitations in describing 1-MT interactions.
    • Accurate modeling of CMH requires incorporating hydration effects.
    • Further refinements are needed for comprehensive analysis of DNA base complex interactions.