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Related Experiment Videos

Elastin and collagen in the normal and obstructed urinary bladder

R Cortivo, F Pagano, G Passerini

    British Journal of Urology
    |April 1, 1981
    PubMed
    Summary

    Urinary bladder obstruction alters elastin and collagen. Elastin increased in newborns and adults with obstruction, while collagen remained unchanged, suggesting elastin

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    Area of Science:

    • Urology
    • Biochemistry
    • Histology

    Background:

    • Urinary bladder wall composition changes with obstruction.
    • Elastin and collagen are key structural proteins in the bladder wall.

    Purpose of the Study:

    • To investigate the histological and chemical changes in elastin and collagen content in normal versus obstructed urinary bladders across different age groups.

    Main Methods:

    • Histological examination of bladder tissue.
    • Chemical analysis of elastin and collagen content.
    • Study included three age groups: infants, children, and adults with varying degrees of bladder outlet obstruction.

    Main Results:

    • Increased elastic tissue was observed in newborns and adults with bladder obstruction.

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  • Collagen content did not significantly vary across studied groups.
  • Elastin in pathological bladders showed an increase in polar amino acids compared to normal bladders.

    • Conclusions:

    • Urinary bladder obstruction impacts elastin content, particularly in newborns and adults.
    • Ageing also contributes to increased elastin in normal bladders.
    • Collagen levels appear unaffected by obstruction or ageing in this study.