Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extrahypothalamic vasopressin in human brain

M N Rossor, L L Iversen, J Hawthorn

    Brain Research
    |June 15, 1981
    PubMed
    Summary

    Researchers mapped arginine vasopressin in the human brain. High concentrations were found in the hypothalamus, locus coeruleus, and substantia nigra, suggesting potential roles in neurotransmission.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A multiplanet system of super-Earths orbiting the brightest red dwarf star GJ 887.

    Science (New York, N.Y.)·2020
    Same author

    Quality of life assessments in advanced breast cancer: should there be more consistency?

    European journal of cancer care·2012
    Same author

    Effect of angiotensin-converting enzyme inhibitor on response of plasma renin activity and aldosterone to tilting in man.

    British journal of clinical pharmacology·2012
    Same author

    Global revascularization.

    Ochsner journal·2011
    Same author

    Dopaminergic mechanisms in schizophrenia.

    Proceedings of the Royal Society of Medicine·2010
    Same author

    Neuropeptides and their peptidases: Functional considerations.

    Neurochemistry international·2010

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Neuroanatomy

    Background:

    • Arginine vasopressin (AVP) is a key neuropeptide involved in various physiological functions.
    • Understanding AVP distribution in the human brain is crucial for elucidating its roles in behavior and disease.

    Purpose of the Study:

    • To investigate the detailed distribution of arginine vasopressin (AVP) immunoreactivity in post-mortem human brain tissue.
    • To compare the characteristics of extrahypothalamic AVP with hypothalamic AVP.

    Main Methods:

    • Radioimmunoassay (RIA) was employed to quantify AVP levels.
    • Immunological and chromatographic techniques were used to characterize AVP.

    Main Results:

    • The highest AVP concentrations were detected in the hypothalamus.
    • Substantial AVP immunoreactivity was also observed in the locus coeruleus, periaqueductal gray, and substantia nigra (compacta and reticulata).
    • Lower concentrations of AVP were found in the globus pallidus.

    Conclusions:

    • Extrahypothalamic AVP is immunologically and chromatographically similar to hypothalamic AVP.
    • High AVP levels in the locus coeruleus may influence noradrenergic transmission.
    • This study provides a detailed map of AVP distribution in the human brain, highlighting potential novel functions.

    Related Experiment Videos