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Related Experiment Videos

Blood components in a 70-year-old population

S Landahl, R Jagenburg, A Svanborg

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |May 1, 1981
    PubMed
    Summary

    This study analyzed 30 blood components in 973 70-year-olds, finding that reference values for normally distributed components are reliable even with disease. Asymmetrical distributions, however, require careful consideration when excluding diseased individuals.

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    Area of Science:

    • Gerontology
    • Clinical Chemistry
    • Biostatistics

    Background:

    • Blood component concentrations naturally change with age.
    • Establishing accurate reference values is crucial for clinical interpretation in older adults.

    Purpose of the Study:

    • To determine concentrations of 30 common blood components in 70-year-olds.
    • To assess the impact of excluding individuals with definable diseases on blood component distribution and reference values.

    Main Methods:

    • Analysis of 30 blood components in a representative sample of 973 70-year-old men and women from the "70-year-old people in Göteborg" study.
    • Statistical analysis of concentration distributions (Gaussian vs. asymmetrical) with and without exclusion of individuals with definable diseases or treatments.
    • Calculation of reference intervals for key blood components.

    Main Results:

    • 13 blood components exhibited Gaussian distribution, unaffected by disease exclusion.
    • 3 components shifted to a decreased 97.8% concentration level after disease exclusion.
    • 14 components showed asymmetrical distributions in both total and disease-free groups, with distributions becoming more pronounced after exclusion.

    Conclusions:

    • Reference values for normally distributed blood components in 70-year-olds can be established without excluding individuals with definable diseases.
    • Asymmetrical distributions necessitate careful consideration of disease exclusion for accurate reference interval determination.
    • The study provides specific reference intervals for common blood components in 70-year-olds, highlighting age-related changes and distribution patterns.

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