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Urinary polyamines in preterm infants

M Perlman, W Y Chan, T Z Ramadan

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |June 2, 1981
    PubMed
    Summary
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    Urinary polyamine levels, including putrescine and spermidine, differ between preterm and full-term infants. Preterm infants show higher levels at term-equivalent age, with specific alterations linked to hyperbilirubinemia and liver disease.

    Area of Science:

    • Biochemistry
    • Neonatal Medicine
    • Pediatric Physiology

    Background:

    • Polyamines are essential for cell growth and differentiation.
    • Urinary polyamine excretion patterns in neonates are not fully understood.
    • Preterm infants represent a unique population with distinct physiological needs.

    Purpose of the Study:

    • To investigate urinary polyamine (putrescine, spermidine) levels in preterm and full-term infants.
    • To compare polyamine excretion in preterm infants from birth to 22 weeks with full-term infants.
    • To explore correlations between polyamine levels, growth, and specific clinical conditions.

    Main Methods:

    • Urine samples collected from 22 preterm infants (mean 30.0 weeks gestation) and full-term infants.
    • Analysis of urinary putrescine and spermidine concentrations.

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  • Comparison of polyamine levels based on postnatal age, postconceptional age, and clinical status.

    • Main Results:

    • Significant decline in urinary putrescine and spermidine with increasing postnatal age in preterm infants.
    • Preterm infants exhibited higher urinary polyamine levels than full-term infants at equivalent postconceptional ages.
    • Increased urinary spermidine (and spermidine/putrescine ratio) associated with hyperbilirubinemia.
    • Elevated urinary putrescine and spermidine levels observed in infants with liver disease.

    Conclusions:

    • Urinary polyamine profiles change with age in preterm infants.
    • Preterm infants have distinct urinary polyamine excretion patterns compared to full-term infants.
    • Urinary polyamine levels may serve as potential biomarkers for hyperbilirubinemia and liver disease in neonates.