Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic morphology in obesity

S M Nasrallah, C E Wills, J T Galambos

    Digestive Diseases and Sciences
    |April 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Obesity causes liver damage similar to alcohol abuse. Histopathology in obese individuals revealed significant steatosis, fibrosis, and even cirrhosis, mirroring alcoholic liver disease findings.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Implementing a completely Web-based nursing research course: instructional design, process, and evaluation considerations.

    The Journal of nursing education·2001
    Same author

    On the role of framing effects in assessment of health-related utilities.

    Medical decision making : an international journal of the Society for Medical Decision Making·1999
    Same author

    Nurses' judgments regarding seclusion and restraint of psychiatric patients: a social judgment analysis.

    Research in nursing & health·1999
    Same author

    A controversy in scaling of subjective states: magnitude estimation versus category rating methods.

    Research in nursing & health·1994
    Same author

    Judgment processes for medication acceptance: self-reports and configural information use.

    Medical decision making : an international journal of the Society for Medical Decision Making·1994
    Same author

    A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone. I. Short-term effects on liver function.

    The American journal of gastroenterology·1991

    Area of Science:

    • Hepatology
    • Gastroenterology
    • Obesity Medicine

    Background:

    • Nonalcoholic fatty liver disease (NAFLD) is a growing concern in obese populations.
    • Histopathological changes in the liver of obese individuals require detailed characterization.
    • Understanding these changes is crucial for early diagnosis and management.

    Purpose of the Study:

    • To evaluate the spectrum of hepatic morphological changes in obese subjects.
    • To compare these changes with those typically seen in alcoholic liver injury.

    Main Methods:

    • Retrospective analysis of 242 liver biopsy specimens from nonalcoholic obese individuals.
    • Histopathological examination to assess steatosis, inflammation, fibrosis, and cirrhosis.

    Related Experiment Videos

    Main Results:

    • Steatosis was observed in 59.7% of subjects, with moderate to severe steatosis in 28.7%.
    • Features resembling alcoholic hepatitis were present in 8.7% of cases.
    • Fibrosis was noted in 31.9% (mild 26.1%, moderate 5.8%), and cirrhosis in 2.7%.

    Conclusions:

    • Histopathological liver changes in obese subjects significantly overlap with those of alcoholic liver injury.
    • Obesity-related liver disease shares common pathological pathways with alcohol-induced liver damage.
    • These findings highlight the severity of liver pathology associated with obesity.