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Intraperitoneal coagulation in chronic liver disease ascites
Digestive Diseases and Sciences
|June 1, 1981
Summary
Patients with chronic liver disease and ascites show evidence of active blood clotting within the abdominal fluid. This study detected fibrin monomer, indicating intraperitoneal coagulation is common in ascites patients.
Area of Science:
- Hepatology
- Hematology
- Internal Medicine
Background:
- Ascites is a common complication of chronic liver disease.
- The presence and activity of coagulation within ascites fluid are not well understood.
Purpose of the Study:
- To investigate for in vivo evidence of active coagulation within ascites in patients with chronic liver disease.
- To detect the presence of fibrin monomer as an indicator of intraperitoneal coagulation.
Main Methods:
- Twenty patients diagnosed with ascites due to chronic liver disease were included.
- Ascites fluid was analyzed for fibrin monomer, fibrin/fibrinogen degradation products, and fibrinogen levels.
Main Results:
- All tested patients exhibited increased levels of fibrin monomer in their ascites.
- Elevated fibrin/fibrinogen degradation products were observed in all patients.
- Absent or low levels of fibrinogen were detected in the ascites of all patients.
Conclusions:
- The findings confirm the presence of active intraperitoneal coagulation in patients with ascites of chronic liver disease.
- Fibrin monomer detection serves as a reliable indicator of ongoing coagulation within ascites.
- Understanding ascites coagulation may lead to new therapeutic strategies for liver disease complications.