Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Factors altering thyroid hormone metabolism

J Robbins

    Environmental Health Perspectives
    |April 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Thyroid hormone metabolism involves deiodination, producing active 3,5,3'-triiodothyronine (T3) and inactive reverse T3 (rT3). Changes in this pathway cause the "low T3 syndrome," impacting thyroid function tests.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Author Correction: Universal DNA methylation age across mammalian tissues.

    Nature aging·2023
    Same author

    Universal DNA methylation age across mammalian tissues.

    Nature aging·2023
    Same author

    Oxygennesis for the Instantaneous Production of Pure Oxygen without Heat.

    Chicago medical examiner·2023
    Same author

    Provision of High Protein Foods Slows the Age-Related Decline in Nutritional Status in Aged Care Residents: A Cluster-Randomised Controlled Trial.

    The journal of nutrition, health & aging·2023
    Same author

    Effect of dietary sources of calcium and protein on hip fractures and falls in older adults in residential care: cluster randomised controlled trial.

    BMJ (Clinical research ed.)·2021
    Same author

    Diagnosis of gestational diabetes during the pandemic: what is the risk of falling through the net?

    Diabetic medicine : a journal of the British Diabetic Association·2020
    Same journal

    A New Start.

    Environmental health perspectives·2026
    Same journal

    Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.

    Environmental health perspectives·2026
    Same journal

    Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.

    Environmental health perspectives·2026
    Same journal

    Comparison of Temperature-Mortality Associations across the Middle East Using Different Exposure Estimation Approaches.

    Environmental health perspectives·2026
    Same journal

    Workflow for Statistical Analysis of Environmental Mixtures.

    Environmental health perspectives·2026
    Same journal

    Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

    Environmental health perspectives·2026
    See all related articles

    Area of Science:

    • Endocrinology
    • Molecular Biology
    • Biochemistry

    Background:

    • Thyroxine (T4) metabolism is crucial for thyroid hormone regulation.
    • Peripheral deiodination of T4 generates active 3,5,3 -triiodothyronine (T3) and inactive reverse T3 (rT3).
    • Tissue-specific T3 generation influences circulating and intracellular hormone levels.

    Purpose of the Study:

    • To review the deiodination pathways of thyroxine metabolism.
    • To highlight the significance of T3 and rT3 production.
    • To discuss the implications of altered deiodination, including the low T3 syndrome.

    Main Methods:

    • Review of existing literature on thyroid hormone deiodination.
    • Focus on the enzymatic reactions involved in T4 metabolism.

    Related Experiment Videos

  • Analysis of physiological and pathological factors affecting deiodination.

    • Main Results:

    • Approximately 80% of T3 is produced extrathyroidally via deiodination.
    • Different tissues exhibit varying patterns of intracellular T3 generation and release.
    • Perturbations in deiodination lead to decreased T3 and increased rT3 levels (low T3 syndrome).

    Conclusions:

    • Deiodination is a key regulatory step in thyroid hormone action.
    • The low T3 syndrome, induced by various factors, has significant clinical implications.
    • Understanding deiodination is vital for interpreting thyroid function tests and assessing the body's response to stress and toxins.