Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromosomal aberrations and bone marrow toxicity

J A Heddle, M F Salamone

    Environmental Health Perspectives
    |June 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    New approaches to antimutagenesis.

    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer·2004
    Same author

    The influence of dietary flaxseed and other grains, fruits and vegetables on the frequency of spontaneous chromosomal damage in mice.

    Mutation research·2004
    Same author

    Effect of dietary supplementation on the frequency of spontaneous lacZ mutations in the developing colon.

    Mutation research·2004
    Same author

    Further characterization and validation of gpt delta transgenic mice for quantifying somatic mutations in vivo.

    Environmental and molecular mutagenesis·2001
    Same author

    A test of the mutagenicity of cooked meats in vivo.

    Mutagenesis·2001
    Same author

    Differential mutation of transgenic and endogenous loci in vivo.

    Mutation research·2000

    Structural chromosomal aberrations are key to bone marrow toxicity, detectable by the micronucleus test. This assay identifies clastogens, including some carcinogens, highlighting cell division

    Area of Science:

    • Toxicology
    • Genetics
    • Cell Biology

    Background:

    • Chromosomal aberrations are critical proximate causes of bone marrow toxicity.
    • Numerical aberrations (aneuploidy, polyploidy) are rarely induced by chemicals.
    • Structural aberrations directly cause cell death, contributing significantly to toxicity.

    Purpose of the Study:

    • To discuss the role of chromosomal aberrations in bone marrow toxicity.
    • To evaluate the utility of the micronucleus test in detecting clastogens.
    • To explore the relationship between chromosomal damage, cell division, and carcinogenicity.

    Main Methods:

    • The study focuses on the micronucleus test using polychromatic erythrocytes.
    • This method detects agents (clastogens) that induce structural chromosomal aberrations.

    Related Experiment Videos

  • Consideration of cell division's role in damage expression and cell cycle stage effects.

    • Main Results:

    • The micronucleus test effectively detects clastogens, including many carcinogens.
    • Only a small fraction of chemicals are identified as clastogens.
    • Cell division is crucial for the manifestation of chromosomal damage.

    Conclusions:

    • Structural chromosomal aberrations are significant contributors to bone marrow toxicity.
    • The micronucleus test is a valuable tool for identifying clastogenic agents.
    • A proposed mechanism links chromosomal aberrations to carcinogenicity.