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Increase in lipolysis and decrease in plasma-heparin lipoprotein lipase activity and alpha 1 lipoprotein level after
European Journal of Clinical Pharmacology
|January 1, 1981
Summary
Aminophylline treatment significantly increased free fatty acids and reduced lipoprotein lipase and alpha 1 lipoprotein. However, it did not affect hepatic triglyceridase, other lipoproteins, cholesterol, or triglycerides.
Area of Science:
- Biochemistry
- Pharmacology
- Metabolic Research
Background:
- Aminophylline is a bronchodilator with known metabolic effects.
- Understanding its impact on lipid metabolism is crucial for patient management.
Purpose of the Study:
- To investigate the effects of intravenous aminophylline on plasma free fatty acids and lipoprotein metabolism.
- To assess the impact on key lipid-metabolizing enzymes like lipoprotein lipase and hepatic triglyceridase.
Main Methods:
- Administration of intravenous aminophylline (0.48 g single dose, then 0.96 g/day for three days).
- Measurement of plasma free fatty acids, post-heparin lipoprotein lipase, and post-heparin hepatic triglyceridase.
- Analysis of various lipoprotein fractions, serum cholesterol, and triglycerides.
Main Results:
- A single dose of aminophylline caused a sharp increase in plasma free fatty acids.
- Three-day treatment significantly reduced post-heparin lipoprotein lipase activity.
- Alpha 1 lipoprotein levels decreased in parallel with lipoprotein lipase; other lipid parameters remained unchanged.
Conclusions:
- Intravenous aminophylline influences free fatty acid levels and lipoprotein lipase activity.
- The drug's effects on lipid metabolism appear specific, not broadly impacting all lipid fractions.