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Theophylline absorption by effervescent activated charcoal (Medicoal)
The Journal of International Medical Research
|January 1, 1981
Summary
Activated charcoal significantly reduced theophylline levels in volunteers. This finding suggests activated charcoal could be a valuable treatment for theophylline poisoning.
Area of Science:
- Pharmacology
- Toxicology
- Clinical Medicine
Background:
- Theophylline is a medication used for respiratory diseases.
- Sustained-release theophylline preparations can lead to toxicity if overdosed.
- Effective management strategies for theophylline poisoning are crucial.
Purpose of the Study:
- To investigate the effect of activated charcoal on plasma theophylline concentrations.
- To evaluate the efficacy of activated charcoal in reducing theophylline bioavailability.
Main Methods:
- Six healthy volunteers received a sustained-release theophylline preparation (675 mg).
- Effervescent activated charcoal (Medicoal) was administered in single and multiple doses.
- Plasma theophylline concentrations were measured to assess bioavailability and peak levels.
Main Results:
- A significant reduction in mean peak plasma theophylline concentrations was observed.
- Mean 12-hour theophylline bioavailability was significantly decreased.
- Activated charcoal demonstrated a clear impact on theophylline pharmacokinetics.
Conclusions:
- Effervescent activated charcoal effectively reduces theophylline absorption.
- Activated charcoal shows potential as an antidote for theophylline overdose.
- Further clinical studies may support the use of activated charcoal in managing theophylline toxicity.