[The effect of proteolytic enzymes (traumanase) on posttraumatic edema]

The edema producing property of a proteolytic enzyme (bromelain), which was parenterally or intraduodenally applied, was investigated in a traumatically induced hindleg edema in rats. Under standardized conditions the hindlegs were squeezed by a wringer and swelling was volumetrically measured. Whereas after enteral application of bromelain a significant reduction of the edema could be observed, the parenteral application only resulted in a minimal therapeutic effect. Although enterally applied enzymes are thought to be degraded in the gut, the better results were obtained after enteral administration of bromelain. This supports the observation that also enzymes can be absorbed by the gut without loosing their biological properties.