Pharmacokinetic analysis and calculations using a program for the minicalculator TI-59

Area of Science:

• Pharmacokinetics
• Computational pharmacology
• Drug development

Background:

• Accurate pharmacokinetic analysis is crucial for understanding drug behavior in the body.
• Existing methods may lack the flexibility for diverse dosing regimens and pharmacokinetic models.
• The TI-59 programmable calculator offers a platform for developing accessible analytical tools.

Purpose of the Study:

• To develop and validate a pharmacokinetic program for the TI-59 calculator.
• To enable analysis of drug plasma concentration profiles from single and multiple doses.
• To facilitate prediction of drug concentrations in clinical settings.

Main Methods:

• Implementation of a pharmacokinetic program on the TI-59 calculator.
• Inclusion of routines for exponential regression, residual analysis, and curve simulation.
• Development of functions for corrections related to infusion and lag-time.
• Calculation of pharmacokinetic parameters using real drug data.

Main Results:

• The program successfully analyzes plasma concentration data for one- and two-compartment models.
• It allows for both single-dose and multiple-dose, steady-state analyses.
• Predictions of mean steady-state concentrations were achievable post-single-dose analysis.
• Practical application demonstrated using naproxen and theophylline data.

Conclusions:

• The TI-59 pharmacokinetic program is a practical tool for clinical analysis.
• It supports diverse pharmacokinetic models and dosing strategies.
• The program enhances the utility of programmable calculators in drug concentration analysis.