Plantar and palmar hyperkeratosis in young castrated women

Three cases of palmar and plantar hyperkeratosis were observed in young women following bilateral oophorectomy. We found this condition, previously described as keratoderma climactericum, to be completely reversible with estrogen replacement therapy. In patients with hysterectomy in addition o oophorectomy, the major risk of estrogen administration, endometrial cancer, does not apply.